Defective interfering viruses and their potential as antiviral agents
Identifieur interne : 000F62 ( Main/Exploration ); précédent : 000F61; suivant : 000F63Defective interfering viruses and their potential as antiviral agents
Auteurs : A. C. Marriott [Royaume-Uni] ; N. J. Dimmock [Royaume-Uni]Source :
- Reviews in Medical Virology [ 1052-9276 ] ; 2010-01.
English descriptors
- Teeft :
- Animal models, Antiviral, Antiviral agents, Antiviral drugs, Biological sciences, Cdna, Cdna clones, Cell culture, Challenge virus, Copyright, Cultured cells, Curr topics microbiol immunol, Cytopathic effect, Defective, Defective rnas, Defective virus, Deletion, Different subtypes, Dimmock, Embryonated eggs, Essential sequences, Foreign genes, Gene segments, Genome, Genomic, Genomic termini, Haemagglutination units, Helper, Helper background, Helper genome, Helper ratio, Helper virus, Helper virus genome, Helper virus replication, Helper viruses, Heterotypic interference, Host cell, Immune response, Immune system, Infectious particles, John wiley sons, Lymphocytic choriomeningitis virus, Magnus effect, Marriott, Molecular parasite, Mouse brain, Mouse lung, Mutant, Novel type, Packaging signals, Partial protection, Particle formation, Particle rnas, Plenum press, Polymerase, Proc natl acad, Protective ability, Protective immunity, Rabies virus, Replication, Respiratory tract, Rna, Semliki forest virus, Sialic acid receptors, Simple deletion, Sindbis virus, Stable propagation, Stomatitis, Terminus, Undiluted passages, Unpublished data, Vaccine, Vesicular, Vesicular stomatitis virus, Viral, Viral polymerase, Viral replication, Virion, Virion proteins, Virol, Virology, Virus, Virus genome, Virus infection, Virus infections, Virus multiplication, Virus particles, Virus preparation, Virus replication.
Abstract
Defective interfering (DI) virus is simply defined as a spontaneously generated virus mutant from which a critical portion of the virus genome has been deleted. At least one essential gene of the virus is deleted, either in its entirety, or sufficiently to make it non‐functional. The resulting DI genome is then defective for replication in the absence of the product(s) of the deleted gene(s), and its replication requires the presence of the complete functional virus genome to provide the missing functions. In addition to being defective DI virus suppresses production of the helper virus in co‐infected cells, and this process of interference can readily be observed in cultured cells. In some cases, DI virus has been observed to attenuate disease in virus‐infected animals. In this article, we review the properties of DI virus, potential mechanisms of interference and progress in using DI virus (in particular that derived from influenza A virus) as a novel type of antiviral agent. Copyright © 2009 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/rmv.641
Affiliations:
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At least one essential gene of the virus is deleted, either in its entirety, or sufficiently to make it non‐functional. The resulting DI genome is then defective for replication in the absence of the product(s) of the deleted gene(s), and its replication requires the presence of the complete functional virus genome to provide the missing functions. In addition to being defective DI virus suppresses production of the helper virus in co‐infected cells, and this process of interference can readily be observed in cultured cells. In some cases, DI virus has been observed to attenuate disease in virus‐infected animals. In this article, we review the properties of DI virus, potential mechanisms of interference and progress in using DI virus (in particular that derived from influenza A virus) as a novel type of antiviral agent. Copyright © 2009 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Marriott, A C" sort="Marriott, A C" uniqKey="Marriott A" first="A. C." last="Marriott">A. C. Marriott</name></noRegion><name sortKey="Dimmock, N J" sort="Dimmock, N J" uniqKey="Dimmock N" first="N. J." last="Dimmock">N. J. Dimmock</name><name sortKey="Marriott, A C" sort="Marriott, A C" uniqKey="Marriott A" first="A. C." last="Marriott">A. C. Marriott</name><name sortKey="Marriott, A C" sort="Marriott, A C" uniqKey="Marriott A" first="A. C." last="Marriott">A. C. Marriott</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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